Background Early administration of appropriate antimicrobials has been correlated with a
better prognosis in patients with bacteremia, but the optimum timing of early antibiotic …

Background Bloodstream infections are associated with high morbidity and mortality, both of
which contribute substantially to healthcare costs. The effects of early administration of …

Introduction A rational use of antibiotics is of paramount importance in order to prevent the
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …

Introduction Increasing antimicrobial costs, reduced development of novel antimicrobials,
and growing antimicrobial resistance necessitate judicious use of available agents …

Background Following emergency department (ED) assessment, patients with infection may
be directly admitted to the intensive care unit (ICU) or alternatively admitted to hospital …

Introduction In patients with severe sepsis and septic shock as cause of Intensive Care Unit
(ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy …

Introduction Few studies have addressed the decision-making process of antibiotic therapy
(AT) in intensive care unit (ICU) patients. Methods In a prospective observational study, all …

Introduction The use of standard doses of β-lactam antibiotics during continuous renal
replacement therapy (CRRT) may result in inadequate serum concentrations. The aim of this …

Introduction Although early institution of adequate antimicrobial therapy is lifesaving in
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …

Introduction Several guidelines recommend initial empirical treatment with two antibiotics
instead of one to decrease mortality in community-acquired pneumonia (CAP) requiring …