Glycosaminoglycans and glycomimetics in the central nervous system

D Rowlands, K Sugahara, JCF Kwok - Molecules, 2015 - mdpi.com
With recent advances in the construction of synthetic glycans, selective targeting of the
extracellular matrix (ECM) as a potential treatment for a wide range of diseases has become …

Glycosaminoglycans

Y Song, F Zhang, RJ Linhardt - The role of glycosylation in health and …, 2021 - Springer
Glycosaminoglycans (GAGs) are important constituents of human glycome. They are
negatively charged unbranched polysaccharides that are usually covalently attached to …

[图书][B] Glycobiology of the nervous system

KY Robert, CL Schengrund - 2014 - Springer
The growing recognition of the structural complexity and functional importance of
glycoconjugates, including glycoproteins, glycolipids, and glycosaminoglycans, in biological …

Priming the cellular glycocalyx for neural development

ML Huang, K Godula - ACS chemical neuroscience, 2014 - ACS Publications
Glycans are important contributors to the development and function of the nervous system
with enormous potential as therapeutic targets. However, a general lack of tools for tailoring …

Glycosaminoglycans in neurodegenerative diseases

W Jin, F Zhang, RJ Linhardt - The Role of Glycosylation in Health and …, 2021 - Springer
Glycosaminoglycans (GAGs) are linear polysaccharides that consist of alternating
disaccharides sequences of uronic acids and/or galactose hexamino sugars most of which …

Introduction to the complexity of cell surface and tissue matrix glycoconjugates

VP Bhavanandan, DC Gowda - Glycobiology of the Nervous System, 2014 - Springer
This chapter provides an overview of structures and functions of complex carbohydrates
(commonly called glycans) that are covalently linked to proteins or lipids to form …

[PDF][PDF] Glycomic approaches toward drug development: therapeutically exploring the glycosaminoglycanome

B Gesslbauer, AJ Kungl - Current opinion in molecular …, 2006 - researchgate.net
The science of decoding the information contained within complex glycan structures is
commonly referred to as' glycomics'. Information flow is usually governed by the binding of …

[PDF][PDF] Glycosaminoglycans: from “cellular glue” to novel therapeutical agents

NK Karamanos, GN Tzanakakis - Current opinion in pharmacology, 2012 - academia.edu
Glycosaminoglycans (GAGs), linear macromolecular heteropolysaccharides consisting of
disaccharide repeating units, are classified into several types. Hexuronic acid based GAGs …

Synthetic probes of glycosaminoglycan function

ME Griffin, LC Hsieh-Wilson - Current opinion in chemical biology, 2013 - Elsevier
Highlights•Synthetic oligosaccharides link specific structures to biological functions.•
Chemoenzymatic methods can produce therapeutically active oligosaccharides.•Biomimetic …

Design, synthesis and biological applications of glycopolypeptides

ZS Clauss, JR Kramer - Advanced Drug Delivery Reviews, 2021 - Elsevier
Carbohydrates play essential structural and biochemical roles in all living organisms.
Glycopolymers are attractive as well-defined biomimetic analogs to study carbohydrate …