Human granulosa cells—stemness properties, molecular cross-talk and follicular angiogenesis

C Dompe, M Kulus, K Stefańska, W Kranc, B Chermuła… - Cells, 2021 - mdpi.com
The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and
granulosa cells (GCs). Two different types of GCs, mural GCs and cumulus cells (CCs) …

The stemness of human ovarian granulosa cells and the role of resveratrol in the differentiation of MSCs—a review based on cellular and molecular knowledge

M Jozkowiak, G Hutchings, M Jankowski, K Kulcenty… - Cells, 2020 - mdpi.com
Ovarian Granulosa Cells (GCs) are known to proliferate in the developing follicle and
undergo several biochemical processes during folliculogenesis. They represent a …

High‐throughput analysis of ovarian granulosa cell transcriptome

E Chronowska - BioMed research international, 2014 - Wiley Online Library
The quality of follicular oocytes depends on interactions with surrounding granulosa cells.
Development of molecular techniques and methods enables better understanding of …

Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential

E Dzafic, M Stimpfel, I Virant-Klun - Journal of assisted reproduction and …, 2013 - Springer
The ovarian follicle represents the basic functional unit of the ovary and consists of an
oocyte, which is surrounded by granulosa cells (GCs). GCs play an important role in the …

Differentiation of human embryonic stem cells into functional ovarian granulosa-like cells

CW Lan, MJ Chen, PS Jan, HF Chen… - The Journal of Clinical …, 2013 - academic.oup.com
Context: Granulosa cells are important for the development and maturation of oocytes. The
dysfunction of granulosa cells may contribute to abnormal folliculogenesis and …

The function of cumulus cells in oocyte growth and maturation and in subsequent ovulation and fertilization

B Turathum, EM Gao, RC Chian - Cells, 2021 - mdpi.com
Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in
mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the …

Research resource: small RNA-seq of human granulosa cells reveals miRNAs in FSHR and aromatase genes

A Velthut-Meikas, J Simm, T Tuuri… - Molecular …, 2013 - academic.oup.com
The granulosa cells in the mammalian ovarian follicle respond to gonadotropin signaling
and are involved in the processes of folliculogenesis and oocyte maturation. Studies on …

The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome

Z Huang, D Wells - Molecular human reproduction, 2010 - academic.oup.com
It is widely recognized that bi-directional communication exists between the human oocyte
and cumulus cells (CCs) which is essential for the production of competent oocytes. CCs …

Transcriptomic diversification of developing cumulus and mural granulosa cells in mouse ovarian follicles

K Wigglesworth, KB Lee, C Emori… - Biology of …, 2015 - academic.oup.com
Cumulus cells and mural granulosa cells (MGCs) have functionally distinct roles in antral
follicles, and comparison of their transcriptomes at a global and systems level can propel …

Granulosa cells from human primordial and primary follicles show differential global gene expression profiles

EH Ernst, S Franks, K Hardy, P Villesen… - Human …, 2018 - academic.oup.com
STUDY QUESTION Can novel genetic candidates involved in follicle dormancy, activation
and integrity be identified from transcriptomic profiles of isolated granulosa cells from human …