Chalcones: Synthetic chemistry follows where nature leads

HA Jasim, L Nahar, MA Jasim, SA Moore, KJ Ritchie… - Biomolecules, 2021 - mdpi.com
Chalcones belong to the flavonoid class of phenolic compounds. They form one of the
largest groups of bioactive natural products. The potential anticancer, anti-inflammatory …

Recent developments in biological aspects of chalcones: the odyssey continues

A Rani, A Anand, K Kumar, V Kumar - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Chalcones are attractive to synthetic chemists because they are easy to
prepare, have a large number of replaceable hydrogens, thereby having significant …

Chalcone: a privileged structure in medicinal chemistry

C Zhuang, W Zhang, C Sheng, W Zhang, C Xing… - Chemical …, 2017 - ACS Publications
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Recent advances in therapeutic chalcones

L Ni, CQ Meng, JA Sikorski - Expert Opinion on Therapeutic Patents, 2004 - Taylor & Francis
Naturally-occurring and synthetic chalcone compounds have shown promising biological
activity and safety profiles and have the potential to be developed as, or more properly …

Synthesis of chalcones derivatives and their biological activities: a review

NAA Elkanzi, H Hrichi, RA Alolayan, W Derafa… - ACS …, 2022 - ACS Publications
Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

Chalcone: a promising bioactive scaffold in medicinal chemistry

G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Synthesis, reactions and application of chalcones: A systematic review

MA Shalaby, SA Rizk, AM Fahim - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
Chalcones are a group of naturally occurring compounds that have biological effects that
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …

Chalcone synthesis, properties and medicinal applications: a review

A Rammohan, JS Reddy, G Sravya, CN Rao… - Environmental …, 2020 - Springer
Chalcone is an aromatic ketone that forms the central core of many important biological
compounds, which are known as chalcones. Chalcones are the biogenetic precursors of …

[HTML][HTML] Diverse molecular targets for chalcones with varied bioactivities

B Zhou, C Xing - Medicinal chemistry, 2015 - ncbi.nlm.nih.gov
Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Synthesis and pharmacological properties of chalcones: a review

SL Gaonkar, UN Vignesh - Research on chemical intermediates, 2017 - Springer
Chalcones and their analogs have been an area of great interest in recent years. Numerous
research papers have been published, and chalcones continue to show promise for new …