The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

Entorhinal grid cells and hippocampal place cells are key systems for mammalian
navigation. By combining information from different sensory modalities, they provide abstract …

Age-related declines in spatial navigation are well-known in human and non-human
species. Studies in non-human species suggest that alteration in hippocampal and other …

Spatial navigation is a skill of determining and maintaining a trajectory from one place to
another. Mild progressive decline of spatial navigation develops gradually during the course …

Spatial navigation is a complex cognitive skill that is necessary for everyday functioning in
the environment. However, navigational skills are not typically measured in most test …

In order to cope with normal cognitive aging we must understand the patterns and
neurofunctional underpinnings of cognitive and behavioral changes throughout adulthood …

Normal aging and mild Alzheimer's disease (AD) are associated with declines in
navigational skills, including allocentric and egocentric representations, cognitive mapping …

Navigation abilities decline with age, partly due to deficits in numerous component
processes. Impaired switching between these various processes (ie, switching navigational …

A progressive loss of navigational abilities in old age has been observed in numerous
studies, but we have only limited understanding of the neural mechanisms underlying this …

Spatial navigation and memory are often seen as heavily intertwined at the cognitive and
neural levels of analysis. We review models that hypothesize a central role for the medial …