[HTML][HTML] Cellular correlates of cortical thinning throughout the lifespan
Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration,
yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology …
yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology …
[HTML][HTML] Brain network architecture constrains age-related cortical thinning
M Petersen, FL Nägele, C Mayer, M Schell… - NeuroImage, 2022 - Elsevier
Age-related cortical atrophy, approximated by cortical thickness measurements from
magnetic resonance imaging, follows a characteristic pattern over the lifespan. Although its …
magnetic resonance imaging, follows a characteristic pattern over the lifespan. Although its …
Age-related cortical thinning in cognitively healthy individuals in their 60s: the PATH Through Life study
Although it is recognized that the human cortex thins with age, longitudinal estimates of
thinning patterns specific to healthy young-old age (< 75 years) individuals are lacking …
thinning patterns specific to healthy young-old age (< 75 years) individuals are lacking …
Cell-specific gene-expression profiles and cortical thickness in the human brain
Neurobiological underpinnings of cortical thickness in the human brain are largely unknown.
Here we use cell-type-specific gene markers to evaluate the contribution of 9 neural cell …
Here we use cell-type-specific gene markers to evaluate the contribution of 9 neural cell …
Greater cortical thinning in normal older adults predicts later cognitive impairment
Cross-sectional studies have shown regional differences in cortical thickness between
healthy older adults and patients with Alzheimer's disease (AD) or mild cognitive impairment …
healthy older adults and patients with Alzheimer's disease (AD) or mild cognitive impairment …
Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span: regions of accelerating and decelerating change
Human cortical thickness and surface area are genetically independent, emerge through
different neurobiological events during development, and are sensitive to different clinical …
different neurobiological events during development, and are sensitive to different clinical …
[HTML][HTML] Cortical remodelling in childhood is associated with genes enriched for neurodevelopmental disorders
Cortical development during childhood and adolescence has been characterised in recent
years using metrics derived from Magnetic Resonance Imaging (MRI). Changes in cortical …
years using metrics derived from Magnetic Resonance Imaging (MRI). Changes in cortical …
Assessment of neurobiological mechanisms of cortical thinning during childhood and adolescence and their implications for psychiatric disorders
Importance Many psychiatric disorders can be conceptualized as disorders of brain
maturation during childhood and adolescence. Discovering the neurobiological …
maturation during childhood and adolescence. Discovering the neurobiological …
High consistency of regional cortical thinning in aging across multiple samples
Cross-sectional magnetic resonance imaging (MRI) studies of cortical thickness and volume
have shown age effects on large areas, but there are substantial discrepancies across …
have shown age effects on large areas, but there are substantial discrepancies across …
Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging
Human aging is accompanied by progressive changes in executive function and memory,
but the biological mechanisms underlying these phenomena are not fully understood. Using …
but the biological mechanisms underlying these phenomena are not fully understood. Using …