Global DNA methylation changes in adults with attention deficit-hyperactivity disorder and its comorbidity with bipolar disorder: links with polygenic scores

D Müller, EH Grevet, NA Figueira da Silva… - Molecular …, 2022 - nature.com
Genetic and environmental factors contribute to the etiology of Attention Deficit-Hyperactivity
Disorder (ADHD). In this sense, the study of epigenetic mechanisms could contribute to the …

The neuroendocrine modulation of global DNA methylation in neuropsychiatric disorders

D Müller, EH Grevet, BS da Silva, MF Charão… - Molecular …, 2021 - nature.com
There is an increasing body of knowledge on the influence of differential DNA methylation of
specific genomic regions in psychiatric disorders. However, fewer studies have addressed …

DNA methylation signature as a biomarker of major neuropsychiatric disorders

Z Shirvani-Farsani, Z Maloum… - Journal of Psychiatric …, 2021 - Elsevier
DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium

J Rijlaarsdam, M Cosin-Tomas, L Schellhas… - Molecular …, 2023 - nature.com
The general psychopathology factor (GPF) has been proposed as a way to capture variance
shared between psychiatric symptoms. Despite a growing body of evidence showing both …

Differentially methylated regions in bipolar disorder and suicide

ME Gaine, F Seifuddin, S Sabunciyan… - American Journal of …, 2019 - Wiley Online Library
The addition of a methyl group to, typically, a cytosine‐guanine dinucleotide (CpG) creates
distinct DNA methylation patterns across the genome that can regulate gene expression …

Preliminary assessment of pre‐morbid DNA methylation in individuals at high genetic risk of mood disorders

RM Walker, JE Sussmann, HC Whalley… - Bipolar …, 2016 - Wiley Online Library
Objectives Accumulating evidence implicates altered DNA methylation in psychiatric
disorders, including bipolar disorder (BD) and major depressive disorder (MDD). It is not …

Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults

P Rovira, C Sánchez-Mora, M Pagerols… - Translational …, 2020 - nature.com
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental
disorder that often persists into adulthood. There is growing evidence that epigenetic …

Genome-wide DNA methylation patterns in persistent attention-deficit/hyperactivity disorder and in association with impulsive and callous traits

M Meijer, M Klein, E Hannon, D Van der Meer… - Frontiers in …, 2020 - frontiersin.org
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often
persists into adulthood. ADHD and related personality traits, such as impulsivity and …

Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder

L Pineda-Cirera, A Shivalikanjli… - Translational …, 2019 - nature.com
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder caused by
an interplay of genetic and environmental factors. Epigenetics is crucial to lasting changes in …

[HTML][HTML] Epigenome-wide association study of attention-deficit/hyperactivity disorder symptoms in adults

J van Dongen, NR Zilhão, K Sugden, BT Heijmans… - Biological …, 2019 - Elsevier
Background Previous studies have reported associations between attention-
deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first …