Background & Aims A proportion of infants and young children with inflammatory bowel
diseases (IBDs) have subtypes associated with a single gene variant (monogenic IBD). We …

Background Most cases of inflammatory bowel disease (IBD) are caused by complex host–
environment interaction. There are a number of conditions associated with a single-gene …

Background: It is important to identify patients with monogenic IBD as management may
differ from classical IBD. In this position statement we formulate recommendations for the …

Objectives: Inflammatory bowel disease [IBD] presenting in early childhood is extremely
rare. More recently, progress has been made to identify children with monogenic forms of …

Background Multiple genes have been implicated by association studies in altering
inflammatory bowel disease (IBD) predisposition. Paediatric patients often manifest more …

OBJECTIVES: Monogenic inflammatory bowel disease (IBD) comprises rare Mendelian
causes of gut inflammation, often presenting in infants with severe and atypical disease. This …

Background and aims Advances in genomic technologies have led to increasing reports of
monogenic inflammatory bowel disease (IBD). However, there has not been a detailed …

Background and aims Multiple monogenic disorders present as very early onset
inflammatory bowel disease (VEO-IBD) or as IBD with severe and atypical features …

Objectives: Inflammatory bowel disease (IBD) is heritable, but a total of 163 variants
commonly implicated in IBD pathogenesis account for only 25% of the heritability. Rare …

AIM To analyze clinical differences between monogenic and nonmonogenic very-early-
onset inflammatory bowel disease (VEO-IBD) and to characterize monogenic IBD …