[HTML][HTML] Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination
Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …
essential for gene expression. Recently, we reported that the Integrator complex can bind …
[HTML][HTML] The integrator complex attenuates promoter-proximal transcription at protein-coding genes
The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a
central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in …
central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in …
Structural basis of Integrator-mediated transcription regulation
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates
paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription …
paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription …
[HTML][HTML] Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci
Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …
Structural basis of INTAC-regulated transcription
H Zheng, Q Jin, X Wang, Y Qi, W Liu, Y Ren… - Protein & …, 2023 - academic.oup.com
Eukaryotic transcription by RNA polymerase II (Pol II) is a strictly regulated process that
involves the interplay of numerous factors. Promoter-proximal pausing is a regulatory …
involves the interplay of numerous factors. Promoter-proximal pausing is a regulatory …
Integrator is a global promoter-proximal termination complex
Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …
[HTML][HTML] Elongation/termination factor exchange mediated by PP1 phosphatase orchestrates transcription termination
T Kecman, K Kuś, DH Heo, K Duckett, A Birot… - Cell reports, 2018 - cell.com
Termination of RNA polymerase II (Pol II) transcription is a key step that is important for 3′
end formation of functional mRNA, mRNA release, and Pol II recycling. Even so, the …
end formation of functional mRNA, mRNA release, and Pol II recycling. Even so, the …
Integrator enforces the fidelity of transcriptional termination at protein-coding genes
LF Dasilva, E Blumenthal, F Beckedorff… - Science …, 2021 - science.org
Integrator regulates the 3′-end processing and termination of multiple classes of
noncoding RNAs. Depletion of INTS11, the catalytic subunit of Integrator, or ectopic …
noncoding RNAs. Depletion of INTS11, the catalytic subunit of Integrator, or ectopic …
The Integrator complex cleaves nascent mRNAs to attenuate transcription
Cellular homeostasis requires transcriptional outputs to be coordinated, and many events
post-transcription initiation can dictate the levels and functions of mature transcripts. To …
post-transcription initiation can dictate the levels and functions of mature transcripts. To …
The integrator complex in transcription and development
MS Mendoza-Figueroa, DC Tatomer… - Trends in biochemical …, 2020 - cell.com
The Integrator complex is conserved across metazoans and controls the fate of many
nascent RNAs transcribed by RNA polymerase II (RNAPII). Among the 14 subunits of …
nascent RNAs transcribed by RNA polymerase II (RNAPII). Among the 14 subunits of …