The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

Among the human genome, p53 is one of the first tumor suppressor genes to be discovered.
It has a wide range of functions covering cell cycle control, apoptosis, genome integrity …

The tumor suppressor p53 is a central hub in a molecular network controlling cell
proliferation and death in response to potentially oncogenic conditions, and a wide array of …

The p53 tumor suppressor protein has well-established roles in monitoring various types of
stress signals by activating specific transcriptional targets that control cell cycle arrest and …

It is poorly understood how a single protein, p53, can be responsive to so many stress
signals and orchestrates very diverse cell responses to maintain/restore cell/tissue functions …

The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

Subsequently, with the evolution of longerliving organisms, p53 is thought to have acquired
the ability to respond to oncogenic signals, promoting apoptosis or senescence–a …

It has been four decades since the discovery of p53, the designated 'Guardian of the
Genome'. P53 is primarily known as a master transcription factor and critical tumor …

Highlights•p53 responses to acute DNA damage signals are dispensable for tumor
suppression.•p53 transcriptional activity is critical for tumor suppression.•p53 responds to …