Therapeutic potential of metformin in COVID-19: reasoning for its protective role

SM Samuel, E Varghese, D Büsselberg - Trends in microbiology, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with
increased disease severity and poor clinical outcomes in diabetic patients compared with …

Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing

E Varghese, SM Samuel, A Liskova, P Kubatka… - PLoS …, 2021 - journals.plos.org
Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a …

[HTML][HTML] Diabetes, metformin and the clinical course of Covid-19: outcomes, mechanisms and suggestions on the therapeutic use of metformin

CJ Bailey, M Gwilt - Frontiers in pharmacology, 2022 - frontiersin.org
Objectives: Pre-existing or new diabetes confers an adverse prognosis in people with Covid-
19. We reviewed the clinical literature on clinical outcomes in metformin-treated subjects …

[HTML][HTML] Metformin in COVID-19: a possible role beyond diabetes

S Sharma, A Ray, B Sadasivam - Diabetes research and clinical …, 2020 - ncbi.nlm.nih.gov
It is a lesser-known fact that metformin was originally introduced as an anti-influenza drug
and that glucose-lowering was only one of its side effects [1]. The many pleiotropic effects of …

Risk of metformin in patients with type 2 diabetes with COVID‐19: a preliminary retrospective report

Y Gao, T Liu, W Zhong, R Liu, H Zhou… - Clinical and …, 2020 - Wiley Online Library
The current outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
2) infection has spread across the world. No specific antiviral agents have been adequately …

[HTML][HTML] The efficacy and potential mechanisms of metformin in the treatment of COVID-19 in the diabetics: a systematic review

M Zangiabadian, SA Nejadghaderi… - Frontiers in …, 2021 - frontiersin.org
Introduction Diabetes mellitus (DM) is one of the most common comorbidities among
patients with coronavirus disease 2019 (COVID-19) which may exacerbate complications of …

[PDF][PDF] Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with COVID-19 and pre-existing type 2 diabetes

X Cheng, YM Liu, H Li, X Zhang, F Lei, JJ Qin, Z Chen… - Cell metabolism, 2020 - cell.com
The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial
impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and …

Is metformin ahead in the race as a repurposed host-directed therapy for patients with diabetes and COVID-19?

AK Singh, R Singh - Diabetes research and …, 2020 - diabetesresearchclinicalpractice …
Most of the expert consensus to date have suggested avoiding metformin in patients with
diabetes and coronavirus disease-19 (COVID-19), due to an anticipated fear of lactic …

Metformin and Covid-19: focused review of mechanisms and current literature suggesting benefit

S Ibrahim, JR Lowe, CT Bramante, S Shah… - Frontiers in …, 2021 - frontiersin.org
Metformin is the first-line medication for type 2 diabetes, but it also has a long history of
improved outcomes in infectious diseases, such as influenza, hepatitis C, and in-vitro assays …

Metformin and COVID-19: from cellular mechanisms to reduced mortality

AJ Scheen - Diabetes & metabolism, 2020 - Elsevier
Type 2 diabetes mellitus (T2DM) is associated with both poorer clinical outcomes during the
COVID-19 pandemic and an increased risk of death in such hospitalized patients. While the …