Viral infection is controlled by host innate immune cells that express specialized receptors
for viral components. Engagement of these pattern recognition receptors triggers a series of …

Highlights•MAVS recruits various downstream molecules through different domains.•Protein
phosphorylation regulates MAVS-mediated signaling.•MAVS aggregation and activation is …

The innate immune system recognizes nucleic acids during viral infection and stimulates
cellular antiviral responses. Intracellular detection of RNA virus infection is mediated by the …

Mitochondrial antiviral signaling protein (MAVS) functions as a “switch” in the immune signal
transduction against most RNA viruses. Upon viral infection, MAVS forms prion-like …

Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex
signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein …

The mitochondrial antiviral signaling protein (MAVS) mediates the activation of NFκB and
IRFs and the induction of interferons in response to viral infection. In vitro studies have also …

ABSTRACT RNA virus infection is sensed in the cytoplasm by the retinoic acid-inducible
gene I (RIG-I)-like receptors. These proteins signal through the host adaptor protein MAVS to …

The mitochondrial antiviral signaling (MAVS) protein plays a central role in innate antiviral
immunity. Upon recognition of a virus, intracellular receptors of the RIG-I-like helicase family …

Mitochondria have emerged as critical platforms for antiviral innate immune signaling. This
is due in large part to the mitochondrial localization of the innate immune signaling adaptor …

Viral infection triggers host innate immune responses through activation of the transcription
factors NF-κB and IRF3, which coordinately regulate the expression of type-I interferons …