The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …

BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and
characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β …

Amyloid plaques, hallmark neuropathological lesions in Alzheimer's disease (AD) brain, are
composed of the β-amyloid peptide (Aβ). Much evidence suggests that Aβ is central to the …

J. Neurochem.(2012) 120 (Suppl. 1), 55–61. Abstract Our knowledge of the etiology of
Alzheimer's disease (AD) has advanced tremendously since the discovery of amyloid beta …

Amyloid plaques are defining histopathologic lesions in the brains of Alzheimer's disease
(AD) patients and are composed of the amyloid-beta peptide, which is widely considered to …

The identification of the aspartic protease BACE1 (β-secretase) was a defining event in
research aimed at understanding the molecular mechanisms that underlie Alzheimer's …

BACE1 is a key enzyme in the generation of Aβ, the major component of senile plaques in
the brains of Alzheimer's disease patients. We have generated transgenic mice expressing …

Targeting BACE1 (β-site APP cleaving enzyme 1 or β-secretase) is the focus of Alzheimer's
disease (AD) research because this aspartyl protease is involved in the abnormal …

Amyloid plaques, composed of the amyloid β-protein (Aβ), are hallmark neuropathological
lesions in Alzheimer disease (AD) brain. Aβ fulfills a central role in AD pathogenesis, and …

Alzheimer's disease (AD) is a fatal progressive neurodegenerative disorder characterized by
increasing loss in memory, cognition, and function of daily living. Among the many …