Normative modeling is considered one of the most promising avenues towards personalized
medicine. The integration of multimodal, mechanistic and lifespan modeling will play an …

The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …

The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …

Background Personalized or precision medicine has been defined as treatments targeted to
the needs of individual patients based on genetic, biomarker, phenotypic, or psychosocial …

In cell and molecular biology, metabolism is the only system that can be fully simulated at
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …

Highlights•The same disease and an individual's responses to drugs can vary
considerably.•The central reason for these differences is the complexity of the human …

The increasing breadth and depth of resolution in biological and clinical data, including‐
omics and real‐world data, requires advanced analytical techniques like artificial …

Predictive models and simulations addressing the individual progression of diseases are
crucial for the optimization of diagnostic tools and therapeutic decisions en route to precision …

The most common use of any mathematical or statistical model in physiology,
pathophysiology, or therapy evaluation is to organize all relevant components characterizing …

Artificial intelligence (AI) and machine learning (ML) methods are currently widely employed
in medicine and healthcare. A PubMed search returns more than 100,000 articles on these …