Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

MH Cheng, S Zhang, RA Porritt… - Proceedings of the …, 2020 - National Acad Sciences
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a
newly recognized condition in children with recent severe acute respiratory syndrome …

[HTML][HTML] An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations

MH Cheng, S Zhang, RA Porritt, M Arditi, I Bahar - BioRxiv, 2020 - ncbi.nlm.nih.gov
Abstract Multisystem Inflammatory Syndrome in Children (MIS-C) associated with
Coronavirus Disease 2019 (COVID-19) is a newly recognized condition in which children …

[HTML][HTML] Multisystem inflammatory syndrome in children and long COVID: the SARS-CoV-2 viral superantigen hypothesis

M Noval Rivas, RA Porritt, MH Cheng, I Bahar… - Frontiers in …, 2022 - frontiersin.org
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory
disease that may develop weeks after initial SARS-CoV-2 infection or exposure. MIS-C …

[HTML][HTML] HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children

RA Porritt, L Paschold, MN Rivas… - The Journal of …, 2021 - Am Soc Clin Investig
Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory syndrome
associated with SARS-CoV-2 infection, shares clinical features with toxic shock syndrome …

COVID-19–associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome—the superantigen hypothesis

MN Rivas, RA Porritt, MH Cheng, I Bahar… - Journal of Allergy and …, 2021 - jacionline.org
As of mid-September, the novel severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has infected more than 30 million people, resulting in approximately 1 million deaths …

[HTML][HTML] Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

A Ramaswamy, NN Brodsky, TS Sumida, M Comi… - Immunity, 2021 - cell.com
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious
complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 …

[HTML][HTML] Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C)

CN Gruber, RS Patel, R Trachtman, L Lepow, F Amanat… - Cell, 2020 - cell.com
Initially, children were thought to be spared from disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel …

[HTML][HTML] Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

S Mahajan, V Kode, K Bhojak, C Karunakaran… - Scientific Reports, 2021 - nature.com
The COVID-19 pandemic has revealed a range of disease phenotypes in infected patients
with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine …

[HTML][HTML] Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

H Liu, NC Wu, M Yuan, S Bangaru, JL Torres… - Immunity, 2020 - cell.com
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …

[HTML][HTML] Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination

ES Geanes, C LeMaster, ER Fraley, S Khanal… - Scientific Reports, 2022 - nature.com
SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has
resulted in millions of deaths worldwide. Novel coronavirus infections in humans have …