The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease
JC Lambert, A Ramirez, B Grenier-Boley… - Molecular …, 2023 - nature.com
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …
of this component has progressed over the last 10 years, thanks notably to the advent of …
Alzheimer's disease genetics: from the bench to the clinic
Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
The genetic landscape of Alzheimer disease
S Carmona, J Hardy, R Guerreiro - Handbook of clinical neurology, 2018 - Elsevier
Alzheimer disease (AD), a progressive and neurodegenerative disease, is the most common
form of dementia with high incidence in elderly people. Neuropathologically the disease is …
form of dementia with high incidence in elderly people. Neuropathologically the disease is …
The complex genetic architecture of Alzheimer's disease: novel insights and future directions
SJ Andrews, AE Renton, B Fulton-Howard… - …, 2023 - thelancet.com
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
Alzheimer disease: modeling an Aβ-centered biological network
In genetically complex diseases, the search for missing heritability is focusing on rare
variants with large effect. Thanks to next generation sequencing technologies, genome-wide …
variants with large effect. Thanks to next generation sequencing technologies, genome-wide …
Understanding Alzheimer disease at the interface between genetics and transcriptomics
J Verheijen, K Sleegers - Trends in Genetics, 2018 - cell.com
Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …
common neurodegenerative dementia. However, mechanistic insights and improved …
Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score
Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost
importance. Although genetic studies have identified AD-associated SNPs in APOE and …
importance. Although genetic studies have identified AD-associated SNPs in APOE and …