Monoclonal antibodies for malaria prevention

M Aleshnick, M Florez-Cuadros, T Martinson… - Molecular Therapy, 2022 - cell.com
Monoclonal antibodies are highly specific proteins that are cloned from a single B cell and
bind to a single epitope on a pathogen. These laboratory-made molecules can serve as …

[HTML][HTML] Monoclonal antibodies for malaria

T Wells, C Donini - New England Journal of Medicine, 2022 - Mass Medical Soc
A New Approach to Preventing Malaria Monoclonal antibodies are commonly used in the
treatment of diseases, including cancer. A next-generation antibody for the prevention of …

Functional antibodies and protection against blood-stage malaria

A Teo, G Feng, GV Brown, JG Beeson… - Trends in …, 2016 - cell.com
Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …

Malaria vaccines: immunity, models and monoclonal antibodies

L Hviid, L Barfod - Trends in parasitology, 2008 - cell.com
Although experts in the field have agreed on the malaria vaccine technology roadmap that
should be followed (http://www. malariavaccineroadmap. net/), the path towards an effective …

Toward the development of effective transmission-blocking vaccines for malaria

D Nikolaeva, SJ Draper, S Biswas - Expert review of vaccines, 2015 - Taylor & Francis
The continued global burden of malaria can in part be attributed to a complex lifecycle, with
both human hosts and mosquito vectors serving as transmission reservoirs. In preclinical …

Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection

B Sack, SHI Kappe, DN Sather - Expert Review of Vaccines, 2017 - Taylor & Francis
Introduction: An effective malaria vaccine would be considered a milestone of modern
medicine, yet has so far eluded research and development efforts. This can be attributed to …

The future for blood‐stage vaccines against malaria

JS Richards, JG Beeson - Immunology and cell biology, 2009 - Wiley Online Library
Malaria is a leading cause of mortality and morbidity globally, and effective vaccines are
urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …

Antibody-based therapies for malaria

RJ Pleass, AA Holder - Nature Reviews Microbiology, 2005 - nature.com
Antibodies are multifunctional glycoproteins that are found in blood and tissue fluids, and
can protect against malaria by binding and neutralizing malaria parasites and preparing …

Malaria: biology and disease

AF Cowman, J Healer, D Marapana, K Marsh - Cell, 2016 - cell.com
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Monoclonal antibodies—A different approach to combat malaria

JP Daily - New England Journal of Medicine, 2022 - Mass Medical Soc
In 2020, a total of 241 million cases of malaria and 627,000 malaria-related deaths were
reported. 1 In this issue of the Journal, Wu and colleagues2 present a new approach to …