Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Telomeres are protective structures present at the ends of linear chromosomes that are
important in preventing genome instability. Telomeres shorten as a result of cellular …

The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Several monogenic inherited diseases that display features of human …

Telomeres are unique DNA-protein structures that contain noncoding TTAGGG repeats and
telomere-associated proteins. These specialized structures are essential for maintaining …

Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes.
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …

Telomeres in telomerase-negative cells shorten during DNA replication in vitro due to
numerous causes including the inability of DNA polymerases to fully copy the lagging …

Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …

Telomeres are the repetitive DNA sequences and specialized proteins that form the
distinctive structure that caps the ends of linear chromosomes. Telomeres allow cells to …