Caveolin-3 is a muscle-specific protein on the membrane of myocytes correlated with a
variety of cardiovascular diseases. It is now clear that the caveolin-3 plays a critical role in …

Caveolins serve as a platform in plasma membrane associated caveolae to orchestrate
various signaling molecules to effectively communicate extracellular signals into the interior …

Aims Caveolinopathies are a family of genetic disorders arising from alterations of the
caveolin-3 (cav-3) gene. The T78M cav-3 variant has been associated with both skeletal and …

Caveolae are specialized membrane microdomains enriched in cholesterol and
sphingolipids which are present in multiple cell types including cardiomyocytes. Along with …

Rationale Flask-shaped invaginations of the cardiomyocyte sarcolemma called caveolae
require the structural protein caveolin-3 (Cav-3) and host a variety of ion channels …

Abstract Caveolin-3 (Cav-3) plays a critical role in organizing signaling molecules and ion
channels involved in cardiac conduction and metabolism. Mutations in Cav-3 are implicated …

Background—Genome-wide association studies have revealed significant association of
caveolin-1 (Cav1) gene variants with increased risk of cardiac arrhythmias. Nevertheless …

Background Sudden cardiac death (SCD) is the clinical outcome of a lethal arrhythmia that
can develop on the background of unrecognized channelopathies or cardiomyopathies …

Caveolae constitute membrane microdomains where receptors and ion channels
functionally interact. Caveolin-3 (cav-3) is the key structural component of muscular …

In human cardiac ventricular myocytes, caveolin-3 functions as a scaffolding and regulatory
protein for signaling molecules and compartmentalizes ion channels. Our lab has recently …