Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …

Carbonic anhydrase IX (CA IX) is a suitable target for various anticancer strategies. It is a
cell surface protein that is present in human tumors, but not in the corresponding normal …

Carbonic anhydrases (CAs; EC 4.2. 1.1) are well known zinc metalloproteins involved in the
catalysis of a very simple but essential physiological reaction: carbon dioxide hydration to …

Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce
bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases …

Introduction Cancer affects an increasing number of patients each year with an
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …

The carbonic anhydrases (CAs) constitute a family of almost ubiquitous enzymes of
significant importance for many physiological and pathological processes. CAs reversely …

Introduction: Human carbonic anhydrases (CA, EC 4.2. 1.1) IX and XII are tumor-associated
proteins, being part of the molecular machinery that tumor cells build as adaptive responses …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …

Carbonic anhydrase isoform IX (CA IX) is highly overexpressed in many types of cancer. Its
expression, which is regulated by the HIF-1 transcription factor, is strongly induced by …