Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

[HTML][HTML] Unmet medical needs in chronic, non-communicable inflammatory skin diseases

H Ujiie, D Rosmarin, MP Schön, S Ständer… - Frontiers in …, 2022 - frontiersin.org
An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

Cytokine and anti-cytokine therapies for psoriasis and atopic dermatitis

RP Numerof, K Asadullah - BioDrugs, 2006 - Springer
Since the discovery of cytokines as key mediators in inflammation, targeting the cytokine
network has represented a promising therapeutic approach. Psoriasis and atopic dermatitis …

Systemic therapies in atopic dermatitis: the pipeline

Y Renert-Yuval, E Guttman-Yassky - Clinics in Dermatology, 2017 - Elsevier
Atopic dermatitis (AD), the most prevalent inflammatory skin disease, is characterized by
robust T-cell activation. The disease has several subtypes, all having a common T helper …

[PDF][PDF] Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine

W Alwan, FO Nestle - Clin Exp Rheumatol, 2015 - clinexprheumatol.org
Psoriasis is a common, chronic inflammatory skin disease associated with multi-system
manifestations including arthritis and obesity. Our knowledge of the aetiology of the …

New era of biologic therapeutics in atopic dermatitis

E Guttman-Yassky, N Dhingra… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is a common inflammatory skin disease regulated by
genetic and environmental factors. Both skin barrier defects and aberrant immune …

[HTML][HTML] The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment

P Facheris, J Jeffery, E Del Duca… - Cellular & Molecular …, 2023 - nature.com
Atopic dermatitis (AD) is the most common inflammatory skin disease, and it is considered a
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …

[HTML][HTML] Pathophysiology of atopic dermatitis and psoriasis: implications for management in children

R Chovatiya, JI Silverberg - Children, 2019 - mdpi.com
Atopic dermatitis (AD) and psoriasis are chronic inflammatory skin diseases associated with
a significant cutaneous and systemic burden of disease as well as a poor health-related …

Strategies to improve outcomes in psoriatic arthritis

C Ritchlin, JU Scher - Current rheumatology reports, 2019 - Springer
Abstract Purpose of Review The therapeutic response to biologic agents in psoriasis is
significantly higher than observed in psoriatic arthritis (PsA). In this review, specific actions to …

Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases

T Litman - Apmis, 2019 - Wiley Online Library
The current state, tools, and applications of personalized medicine with special emphasis on
inflammatory skin diseases like psoriasis and atopic dermatitis are discussed. Inflammatory …