Considerable variations exist in the clinical presentation of psychiatric disorders. For any
given diagnostic construct, there are several thousand combinations of symptoms that can …

Despite agreement that chronic schizophrenia is clinically heterogeneous, no system of
subclassification has received general acceptance. Most methods for defining subgroups …

Although schizophrenia is often characterized as a heterogeneous disorder, efforts to
validate stable and meaningful subtypes have met with limited success. Thus, the issue of …

Support continues to grow for the idea that schizophrenia, as we know it, is not a discrete
illness but rather a generalized symptom of brain dysfunction. Distinct groups of individuals …

Schizophrenia is a complex and heterogeneous syndrome. Whether quantitative imaging
biomarkers can identify discrete subgroups of patients as might be used to foster …

Using machine learning, we recently decomposed the neuroanatomical heterogeneity of
established schizophrenia to discover two volumetric subgroups—a 'lower brain …

The identification of the cerebral substrates of psychoses such as schizophrenia and bipolar
disorder is likely hampered by its biological heterogeneity, which may contribute to the low …

Based on a strategy developed by Seidman et al.(Seidman, LJ, Faraone, SV, Kremen, WS,
Pepple, JR, Lyons, MJ, Tsuang, MT, 1993. Neuropsychological dysfunctions in the non …

Background Similarities among schizophrenia (SZ), schizoaffective disorder (SAD) and
bipolar disorder (BP) including clinical phenotypes, brain alterations and risk genes, make it …

Background: Schizophrenia is a multifaceted mental disorder characterized by cognitive,
perceptual, and affective symptom dimensions. This heterogeneity at the phenomenological …