More surprises lying ahead. The endocannabinoids keep us guessing

D Piomelli - Neuropharmacology, 2014 - Elsevier
The objective of this review is to point out some important facts that we don't know about
endogenous cannabinoids—lipid-derived signaling molecules that activate CB 1 …

Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol

ML Yates, EL Barker - Molecular pharmacology, 2009 - ASPET
The cannabinoid field is currently an active research area. Anandamide (AEA) and 2-
arachidonoylglycerol (2-AG) are the most characterized endogenous cannabinoids (also …

Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids

A Luchicchi, M Pistis - Molecular neurobiology, 2012 - Springer
Since the discovery of endocannabinoids and their receptors, two major members of the
endocannabinoid family, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been …

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

JZ Long, W Li, L Booker, JJ Burston, SG Kinsey… - Nature chemical …, 2009 - nature.com
Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the
cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by …

Endocannabinoids and their actions

M Maccarrone, A Finazzi-Agró - 2002 - Elsevier
Endocannabinoids are a new class of lipid mediators, which includes amides and esters of
long-chain polyunsaturated fatty acids. Anandamide (I) and 2-arachidonoylglycerol (II) are …

[PDF][PDF] The multiple pathways of endocannabinoid metabolism: a zoom out

S Vandevoorde, DM Lambert - Chemistry & biodiversity, 2007 - Citeseer
Abbreviations.–AA, Arachidonic acid; AEA, arachidonoylethanolamide (anandamide); 2-AG,
2-arachidonoylglycerol; CNS, central nervous system; COX, cyclooxygenase; CRC …

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

BF Cravatt, AH Lichtman - Current opinion in chemical biology, 2003 - Elsevier
The medicinal properties of exogenous cannabinoids have been recognized for centuries
and can largely be attributed to the activation in the nervous system of a single G-protein …

Endocannabinoid biosynthesis and inactivation, from simple to complex

GG Muccioli - Drug discovery today, 2010 - Elsevier
Cannabinoid receptors, the primary molecular targets of the endocannabinoid system, are
activated by specific bioactive lipids termed 'endocannabinoids'. These lipid transmitters are …

Why endocannabinoids are not all alike

V Di Marzo, L Cristino - Nature neuroscience, 2008 - nature.com
Why endocannabinoids are not all alike | Nature Neuroscience Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Molecular biology of the enzymes that degrade endocannabinoids

RA Puffenbarger - Current Drug Targets-CNS & Neurological …, 2005 - ingentaconnect.com
Endocannabinoid circuits have been shown to regulate a number of important pathways
including pain, feeding, memory and motor coordination. Direct manipulation of …