Although breast cancer is a heterogeneous disease that is challenging to characterize and
treat, the recent explosion of genetic and epigenetic research may help improve these …

Breast carcinogenesis involves genetic and epigenetic alterations that cause aberrant gene
function. Recent progress in the knowledge of epigenomics has had a profound impact on …

More women die from breast cancer across the world today than from any other type of
malignancy. The clinical course of breast cancer varies tremendously between patients …

Breast cancer is not a single disease, but rather is composed of distinct subtypes associated
with different clinical outcomes. Understanding this heterogeneity is key for the development …

Breast cancer, like other cancers, is a genetic disease. The disease is caused by acquired
molecular alterations during the lifetime of an individual and by inherited mutant genes. Risk …

The global burden of breast cancer (BC) is increasing significantly. This trend is caused by
several factors such as late diagnosis, limited treatment options for certain BC subtypes …

Breast cancer is noted for disparate clinical behaviors and patient outcomes, despite
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …

Simple Summary Breast cancer is a heterogeneous disease that is driven by genetic,
epigenetic and phenotypic modifications and is also affected by the microenvironment and …

This review summarizes advances in our understanding of the genomic and epigenomic
abnormalities in breast cancers that are being revealed by the increasingly powerful suite of …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …