Introduction Patients in intensive care units (ICU) are often developing severe infections in
which are associated with significant mortality rates. A number of novel technologies for the …

Treatment of suspected infections in critically ill patients requires the timely initiation of
appropriate antimicrobials and rapid de-escalation of unnecessary broad-spectrum …

Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …

Effective treatment of sepsis not only demands prompt administration of appropriate
antimicrobials but also requires precise dosing to enhance the likelihood of patient survival …

Nosocomial infections continue to be important causes of morbidity and mortality in modern
hospitals. The large volume and often excessive use of antimicrobial agents, particularly in …

The high prevalence of infectious diseases in the intensive care unit (ICU) and consequently
elevated pressure for immediate and effective treatment have led to increased antimicrobial …

Background The clinical effects of varying pharmacokinetic exposures of antibiotics
(antibacterials and antifungals) on outcome in infected critically ill patients are poorly …

Critically ill patients with severe infections often have altered pharmacokinetic and
pharmacodynamic variables that lead to challenging treatment decisions. These altered …

Critically ill patients with infection in the intensive care unit (ICU) would certainly benefit from
timely bacterial identification and effective antimicrobial treatment. Diagnostic techniques …

The life-saving benefits of prompt, appropriate therapy are well documented. Studies have
consistently demonstrated that delivery of early, appropriate antimicrobials reduces the …