Purpose Consensus is needed on conceptual foundations, terminology and relationships
among the various self‐controlled “trigger” study designs that control for time‐invariant …

Background Observational studies are widely used in pharmacoepidemiology. Several
designs can be used, in particular self-controlled designs (case-crossover and self …

Background Despite the frequent use of self-controlled methods in
pharmacoepidemiological studies, the factors that may bias the estimates from these …

Self‐controlled observational study designs, such as the case–crossover design and the self‐
controlled case series, are reviewed, and their respective rationale, strengths and limitations …

Background Case-only designs have been used since late 1980's. In these, as opposed to
case-control or cohort studies for instance, only cases are required and are self-controlled …

Large health care databases are used extensively for pharmacoepidemiologic studies.
Unique methodological issues arise when applying self-controlled designs (ie, using within …

Purpose To assess case‐only designs for surveillance with administrative databases.
Methods We reviewed literature on two designs that are observational analogs to crossover …

Background Observational healthcare data offer the potential to enable identification of risks
of medical products, but appropriate methodology has not yet been defined. The self …

Characterization of relationships between time-varying drug exposures and adverse events
(AEs) related to health outcomes represents the primary objective in postmarketing drug …

Self-Controlled Case Series Studies: A Modelling Guide with R provides the first
comprehensive account of the self-controlled case series (SCCS) method, a statistical …