Abstract The SARS-CoV-2 papain-like protease (PL pro) and main protease (M pro) are
nucleophilic cysteine enzymes that catalyze the hydrolysis of the viral polyproteins …

As the pathogen of COVID‐19, SARS‐CoV‐2 encodes two essential cysteine proteases that
process the pathogen's two large polypeptide products pp1a and pp1ab in the human cell …

Both severe acute respiratory syndrome coronavirus 1 and 2 (SARS-CoV-1 and SARS-CoV-
2) encode a papain-like protease (PLpro), which plays a vital role in viral propagation. PLpro …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for
COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The …

The COVID-19 pandemic has emerged as the biggest life-threatening disease of this
century. Whilst vaccination should provide a long-term solution, this is pitted against the …

ABSTRACT SARS-CoV-2 papain-like protease (PLpro) could facilitate viral replication and
host immune evasion by respectively hydrolyzing viral polyprotein and host ubiquitin …

The ubiquitin proteasome system (UPS), particularly its deubiquitinating enzymes (DUBs),
play a key role in the replication cycle of coronaviruses. The SARS-CoV-2 papain-like …

Conjugation or deconjugation of ubiquitin (Ub) or ubiquitin‐like proteins (UBLs) to or from
cellular proteins is a multifaceted and universal means of regulating cellular physiology …

Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which
is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain …

COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political,
socio-economic, and public health consequences. Inhibiting replication represents an …