Inflammasomes are cytosolic polyprotein complexes formed in response to various external
and internal stimuli, including viral and bacterial antigens. The main product of the …

Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting
antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune …

In recent years, scientists studying the molecular mechanisms of inflammation have
discovered an amazing phenomenon–the inflammasome–a component of the innate …

Inflammasomes are protein complexes that form in response to pathogen-derived or host-
derived stress signals. Their activation leads to the production of inflammatory cytokines and …

Stimulation and release of proinflammatory cytokines is an essential step for the activation of
an effective innate host defense, and subsequently for the modulation of adaptive immune …

Review of the activation of inflammasome processes IL-1β and IL-18, which synergize with
IL-23 to promote IL-17 production, by IL-17-secreting γδ T and Th17 cells. NLRs are …

The inflammasome is an important innate immune pathway that regulates at least two host
responses protective against infections:(1) secretion of the proinflammatory cytokines IL‐1β …

Inflammasomes are cytosolic multiprotein complexes that can proteolytically activate
caspase-1. Activated caspase-1 is needed for the maturation and secretion of interleukin (IL) …

Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …

The inflammasome-forming NLRs are well characterized members of a protein complex
mediating the activation of caspase-1 and the cleavage of pro-IL-1β and pro-IL-18 into their …