Novel agents for the pharmacological treatment of alcohol use disorder

EM Burnette, SJ Nieto, EN Grodin, LR Meredith… - Drugs, 2022 - Springer
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Medications for alcohol use disorders: An overview

M Akbar, M Egli, YE Cho, BJ Song… - Pharmacology & …, 2018 - Elsevier
Patients who suffer from alcohol use disorders (AUDs) usually go through various socio-
behavioral and pathophysiological changes that take place in the brain and other organs …

Potential medications for the treatment of alcohol use disorder: an evaluation of clinical efficacy and safety

RZ Litten, BB Wilford, DE Falk, ML Ryan… - Substance …, 2016 - journals.sagepub.com
Alcohol use disorder (AUD), as currently defined in the Diagnostic and Statistical Manual,
5th Edition (DSM–5), is a heterogeneous disorder stemming from a complex interaction of …

Medications development to treat alcohol dependence: a vision for the next decade

RZ Litten, M Egli, M Heilig, C Cui, JB Fertig… - Addiction …, 2012 - Wiley Online Library
More than 76 million people world‐wide are estimated to have diagnosable alcohol use
disorders (AUDs)(alcohol abuse or dependence), making these disorders a major global …

Discovery, development, and adoption of medications to treat alcohol use disorder: goals for the phases of medications development

RZ Litten, DE Falk, ML Ryan… - Alcoholism: Clinical and …, 2016 - Wiley Online Library
For more than 25 years, advances have been made in developing medications to treat
alcohol use disorder (AUD), highlighted by the US Food and Drug Administration's approval …

Alcohol use disorder treatment: Problems and solutions

GF Koob - Annual Review of Pharmacology and Toxicology, 2024 - annualreviews.org
Alcohol use disorder (AUD) afflicts over 29 million individuals and causes more than
140,000 deaths annually in the United States. A heuristic framework for AUD includes a …

Pharmacotherapy for alcohol use disorder: a systematic review and meta-analysis

M McPheeters, EA O'Connor, S Riley, SM Kennedy… - Jama, 2023 - jamanetwork.com
Importance Alcohol use disorder affects more than 28.3 million people in the United States
and is associated with increased rates of morbidity and mortality. Objective To compare …

Overview of alcohol use disorder

HR Kranzler - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
Alcohol is regularly consumed throughout most of the world, including by nearly half the US
population age 12 or older. Heavy drinking, which is also common, contributes to multiple …

Alcohol use disorder: pathophysiology, effects, and pharmacologic options for treatment

RC Wackernah, MJ Minnick, P Clapp - Substance abuse and …, 2014 - Taylor & Francis
Alcohol use disorders (AUD) continue to be a concerning health issue worldwide. Harmful
alcohol use leads to 2.5 million deaths annually worldwide. Multiple options exist for the …

State-of-the-art behavioral and pharmacological treatments for alcohol use disorder

LA Ray, S Bujarski, E Grodin, E Hartwell… - The American journal …, 2019 - Taylor & Francis
Background: Alcohol use disorder (AUD) and its associated consequences remain
significant public health concerns. Given that AUD represents a spectrum of severity …