Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populations
Polygenic scores (PGS) have limited portability across different groupings of individuals (eg,
by genetic ancestries and/or social determinants of health), preventing their equitable use …
by genetic ancestries and/or social determinants of health), preventing their equitable use …
Polygenic scoring accuracy varies across the genetic ancestry continuum
Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …
example, by genetic ancestries and/or social determinants of health), preventing their …
High-resolution portability of 245 polygenic scores when derived and applied in the same cohort
The low portability of polygenic scores (PGS) across global populations is a major concern
that must be addressed before PGS can be used for everyone in the clinic. Indeed …
that must be addressed before PGS can be used for everyone in the clinic. Indeed …
[PDF][PDF] Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort
The low portability of polygenic scores (PGSs) across global populations is a major concern
that must be addressed before PGSs can be used for everyone in the clinic. Indeed …
that must be addressed before PGSs can be used for everyone in the clinic. Indeed …
High trait variability in optimal polygenic prediction strategy within multiple-ancestry cohorts
Polygenic scores (PGS) are individual-level measures that quantify the genetic contribution
to a given trait. PGS have predominantly been developed using European ancestry samples …
to a given trait. PGS have predominantly been developed using European ancestry samples …
Analysis of polygenic score usage and performance across diverse human populations
Studies of the relationship between genetic and phenotypic variation have historically been
carried out on people of European ancestry. Efforts are underway to address this limitation …
carried out on people of European ancestry. Efforts are underway to address this limitation …
[PDF][PDF] Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring
Polygenic scores (PGSs) have emerged as a standard approach to predict phenotypes from
genotype data in a wide array of applications from socio-genomics to personalized …
genotype data in a wide array of applications from socio-genomics to personalized …
mtPGS: Leverage multiple correlated traits for accurate polygenic score construction
Accurate polygenic scores (PGSs) facilitate the genetic prediction of complex traits and aid
in the development of personalized medicine. Here, we develop a statistical method called …
in the development of personalized medicine. Here, we develop a statistical method called …
Recent advances in polygenic scores: translation, equitability, methods and FAIR tools
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …
predisposition to disease, and many potentially clinically useful applications have been …
[HTML][HTML] Calibrated prediction intervals for polygenic scores across diverse contexts
Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide
range of fields from agriculture to personalized medicine. We analyze data from two large …
range of fields from agriculture to personalized medicine. We analyze data from two large …