Reactive oxygen species are known to contribute to tissue damage during injury and
inflammation. However, these species can also be sensed by the cells and trigger …

Previous studies have shown that reactive oxygen species (ROS) enhance arachidonic acid
(AA) release and the subsequent AA metabolism in macrophages. The purpose of this study …

The eicosanoids are centrally involved in the onset and resolution of inflammatory
processes. A key enzyme in eicosanoid biosynthesis during inflammation is group IVA …

Previous studies have demonstrated that U937 cells are able to mobilize arachidonic acid
(AA) and synthesize prostaglandins in response to receptor-directed and soluble stimuli by a …

Reactive oxygen species (ROS) are produced in enzymatic and non-enzymatic reactions
and have important roles in cell signalling but also detrimental effects. ROS-induced …

Over the past few decades, the fundamental concept that the in vivo modulation of levels of
arachidonic acid (AA) is intimately linked to cellular function and human disease has been …

Oxidized phospholipids, such as the products of the oxidation of 1-palmitoyl-2-arachidonoyl-
sn-glycero-3-phosphocholine by nonenzymatic radical attack, are known to be formed in a …

Abstract Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to
numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens …

Arachidonic acid is liberated from the sn-2 position of membrane glycerophospholipids by
phospholipase A,(PLA,), initiating the production of prostaglandins and leukotrienes …

Group VIA calcium-independent phospholipase A 2 (iPLA 2) has been shown to play a
major role in regulating basal phospholipid deacylation reactions in certain cell types. More …