[HTML][HTML] Pan-cancer analysis reveals molecular patterns associated with age

Y Shah, A Verma, AR Marderstein, J White, B Bhinder… - Cell reports, 2021 - cell.com
Older age is a strong risk factor for several diseases, including cancer. The etiology and
biology of age-associated differences among cancers are poorly understood. To address …

[HTML][HTML] Age-associated differences in the cancer molecular landscape

K Chatsirisupachai, C Lagger, JP de Magalhães - Trends in cancer, 2022 - cell.com
Cancer is an age-related disease, as incidence and mortality for most types of cancer
increase with age. However, how molecular alterations in tumors differ among patients of …

Shared genetic and epigenetic changes link aging and cancer

DJ Zabransky, EM Jaffee, AT Weeraratna - Trends in cell biology, 2022 - cell.com
Aging is a universal biological process that increases the risk of multiple diseases including
cancer. Growing evidence shows that alterations in the genome and epigenome, driven by …

Host age is a systemic regulator of gene expression impacting cancer progression

A Beheshti, S Benzekry, JT McDonald, L Ma, M Peluso… - Cancer research, 2015 - AACR
Aging is the major determinant of cancer incidence, which, in turn, is likely dictated in large
part by processes that influence the progression of early subclinical (occult) cancers …

Comprehensive transcriptome profiling in elderly cancer patients reveals aging‐altered immune cells and immune checkpoints

Y Wu, J Wei, X Chen, Y Qin, R Mao… - … Journal of Cancer, 2019 - Wiley Online Library
Aging is the single most significant risk factor for cancer development. However, the
potential impact of aging on cancer microenvironment remains poorly understood. Here, we …

[HTML][HTML] Genomic and molecular features distinguish young adult cancer from later-onset cancer

W Lee, Z Wang, M Saffern, T Jun, K Huang - Cell reports, 2021 - cell.com
Young adult cancer has increased in incidence worldwide, but its molecular etiologies
remain unclear. We systematically characterize genomic profiles of young adult tumors with …

[HTML][HTML] An integrative analysis of the age-associated multi-omic landscape across cancers

K Chatsirisupachai, T Lesluyes, L Paraoan… - Nature …, 2021 - nature.com
Age is the most important risk factor for cancer, as cancer incidence and mortality increase
with age. However, how molecular alterations in tumours differ among patients of different …

[HTML][HTML] Age influences on the molecular presentation of tumours

CH Li, S Haider, PC Boutros - Nature communications, 2022 - nature.com
Cancer is often called a disease of aging. There are numerous ways in which cancer
epidemiology and behaviour change with the age of the patient. The molecular bases for …

Ageing and cancer: a research gap to fill

E Solary, N Abou‐Zeid, F Calvo - Molecular Oncology, 2022 - Wiley Online Library
The complex mechanisms of ageing biology are increasingly understood. Interventions to
reduce or delay ageing‐associated diseases are emerging. Cancer is one of the diseases …

[HTML][HTML] Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice

C Zhang, L Lei, X Yang, K Ma, H Zheng… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Aging has long been thought to be a major risk factor for various types of
cancers. However, accumulating evidence indicates increased resistance of old animals to …