The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
A Salminen - Journal of Molecular Medicine, 2024 - Springer
The accumulation of senescent cells within tissues is a hallmark of the aging process.
Senescent cells are also commonly present in many age-related diseases and in the cancer …
Senescent cells are also commonly present in many age-related diseases and in the cancer …
Upregulation of PD-L1 in Senescence and Aging
Cellular senescence is a stable form of cell cycle arrest associated with proinflammatory
responses. Senescent cells can be cleared by the immune system as a part of normal tissue …
responses. Senescent cells can be cleared by the immune system as a part of normal tissue …
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases
A Salminen - Biogerontology, 2024 - Springer
The accumulation of pro-inflammatory senescent cells within tissues is a common hallmark
of the aging process and many age-related diseases. This modification has been called the …
of the aging process and many age-related diseases. This modification has been called the …
p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells
The accumulation of senescent cells promotes aging, but a molecular mechanism that
senescent cells use to evade immune clearance and accumulate remains to be elucidated …
senescent cells use to evade immune clearance and accumulate remains to be elucidated …
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes
The accumulation of senescent cells is a major cause of age-related inflammation and
predisposes to a variety of age-related diseases. However, little is known about the …
predisposes to a variety of age-related diseases. However, little is known about the …
Immune checkpoint expression and relationships to anti‐PD‐L1 immune checkpoint blockade cancer immunotherapy efficacy in aged versus young mice
Introduction Aging is the biggest cancer risk, and immune checkpoint (IC) inhibition (ICI) is a
revolutionary cancer immunotherapy approach. Nonetheless, there are limited …
revolutionary cancer immunotherapy approach. Nonetheless, there are limited …
Partial restoration of T‐cell function in aged mice by in vitro blockade of the PD‐1/ PD‐L1 pathway
CS Lages, I Lewkowich, A Sproles, M Wills‐Karp… - Aging cell, 2010 - Wiley Online Library
Summary Programmed cell death‐1 (PD‐1) is a newly characterized negative regulator of
immune responses. The interaction of PD‐1 with its ligands (PD‐L1 and PD‐L2) inhibits T …
immune responses. The interaction of PD‐1 with its ligands (PD‐L1 and PD‐L2) inhibits T …
[HTML][HTML] Analysis of the expression and regulation of PD-1 protein on the surface of myeloid-derived suppressor cells (MDSCs)
S Nam, A Lee, J Lim, JS Lim - Biomolecules & therapeutics, 2019 - ncbi.nlm.nih.gov
Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a
heterogeneous cell population frequently observed in cancer, infection, and autoimmune …
heterogeneous cell population frequently observed in cancer, infection, and autoimmune …
Role of PD-1 in immunity and diseases
K Chamoto, M Al-Habsi, T Honjo - Emerging concepts targeting immune …, 2017 - Springer
Immunity developed to defend our bodies from foreign particles, including bacteria and
viruses. Although effector cells responsible for acquired immunity, mainly T cells, and B …
viruses. Although effector cells responsible for acquired immunity, mainly T cells, and B …
A change of PD-1/PD-L1 expression on peripheral T cell subsets correlates with the different stages of Alzheimer's Disease
CT Wu, CI Chu, FY Wang, HY Yang, WS Tseng… - Cell & Bioscience, 2022 - Springer
Background Immune checkpoints are a set of costimulatory and inhibitory molecules that
maintain self-tolerance and regulate immune homeostasis. The expression of immune …
maintain self-tolerance and regulate immune homeostasis. The expression of immune …