Modeling and prediction of flow-induced hemolysis: a review

MM Faghih, MK Sharp - Biomechanics and modeling in mechanobiology, 2019 - Springer
Despite decades of research related to hemolysis, the accuracy of prediction algorithms for
complex flows leaves much to be desired. Fundamental questions remain about how …

On the representation of effective stress for computing hemolysis

P Wu, Q Gao, PL Hsu - Biomechanics and modeling in mechanobiology, 2019 - Springer
Hemolysis is a major concern in blood-circulating devices, which arises due to
hydrodynamic loading on red blood cells from ambient flow environment. Hemolysis …

A multiscale, biophysical model of flow‐induced red blood cell damage

F Vitale, J Nam, L Turchetti, M Behr, R Raphael… - AIChE …, 2014 - Wiley Online Library
A new model for mechanically induced red blood cell damage is presented. Incorporating
biophysical insight at multiple length scales, the model couples flow‐induced deformation of …

A strain-based model for mechanical hemolysis based on a coarse-grained red blood cell model

HM Ezzeldin, MD de Tullio, M Vanella… - Annals of biomedical …, 2015 - Springer
Mechanical hemolysis is a major concern in the design of cardiovascular devices, such as
prosthetic heart valves and ventricular assist devices. The primary cause of mechanical …

A strain‐based flow‐induced hemolysis prediction model calibrated by in vitro erythrocyte deformation measurements

Y Chen, MK Sharp - Artificial organs, 2011 - Wiley Online Library
Hemolysis is caused by fluid stresses in flows within hypodermic needles, blood pumps,
artificial hearts, and other cardiovascular devices. Developers of cardiovascular devices …

A review of hemolysis prediction models for computational fluid dynamics

H Yu, S Engel, G Janiga, D Thévenin - Artificial organs, 2017 - Wiley Online Library
Flow‐induced hemolysis is a crucial issue for many biomedical applications; in particular, it
is an essential issue for the development of blood‐transporting devices such as left …

Significance of extensional stresses to red blood cell lysis in a shearing flow

LA Down, DV Papavassiliou, EA O'Rear - Annals of biomedical …, 2011 - Springer
Traditionally, an empirical power-law model relating hemolysis to shear stress and exposure
time has been used to estimate hemolysis related to flow—however, this basis alone has …

Evaluation of computational models for hemolysis estimation

L Gu, WA Smith - ASAIO journal, 2005 - journals.lww.com
The potential for mechanical erythrocyte damage, or hemolysis, in heart valves and blood
pumps has been estimated using computational fluid dynamics (CFD) analysis, combined …

Multilaboratory study of flow‐induced hemolysis using the FDA benchmark nozzle model

LH Herbertson, SE Olia, A Daly, CP Noatch… - Artificial …, 2015 - Wiley Online Library
Multilaboratory in vitro blood damage testing was performed on a simple nozzle model to
determine how different flow parameters and blood properties affect device‐induced …

Fast three‐dimensional numerical hemolysis approximation

A Garon, MI Farinas - Artificial Organs, 2004 - Wiley Online Library
The in vivo implantation of a mechanical device contributes to hemodynamic disturbances,
which are responsible for damage to the membranes of red blood cells that in turn can lead …