Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke? Discordance between randomised controlled trials and observational studies

AJ Scheen - Diabetes & Metabolism, 2023 - Elsevier
Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular
complication has been less carefully investigated than the risk of cardiovascular mortality …

Effects of SGLT2 inhibitors on stroke and its subtypes in patients with type 2 diabetes: a systematic review and meta-analysis

WH Tsai, SM Chuang, SC Liu, CC Lee, MN Chien… - Scientific reports, 2021 - nature.com
Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown impressive effects
in reducing major vascular events in several randomized controlled trials (RCTs). The …

[HTML][HTML] Comparative effect of glucose-lowering drugs for type 2 diabetes mellitus on stroke prevention: a systematic review and network meta-analysis

JS Kim, G Lee, KI Park, SW Oh - Diabetes & Metabolism …, 2024 - synapse.koreamed.org
Background There is still a lack of research on which diabetic drugs are more effective in
preventing stroke. Our network metaanalysis aimed to compare cerebrovascular benefits …

Effect of new glucose-lowering drugs on stroke in patients with type 2 diabetes: A systematic review and Meta-analysis

J Li, C Ji, W Zhang, L Lan, W Ge - Journal of Diabetes and its …, 2023 - Elsevier
Aims People with diabetes tend to face a higher risk of stroke. Randomized controlled trials
(RCTs) have demonstrated the different outcomes of new glucose-lowering drugs marketed …

GLP-1 receptor agonists and risk of adverse cerebrovascular outcomes in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

M Banerjee, R Pal, S Mukhopadhyay… - The Journal of Clinical …, 2023 - academic.oup.com
Context The effect of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on
ischemic/hemorrhagic stroke and transient ischemic attacks (TIA) in type 2 diabetes mellitus …

SGLT2 inhibitors and risk of stroke in patients with type 2 diabetes: a systematic review and meta‐analysis

M Guo, J Ding, J Li, J Wang, T Zhang… - Diabetes, Obesity …, 2018 - Wiley Online Library
The effects of sodium‐glucose cotransporter 2 (SGLT2) inhibitors on risk of stroke have not
been conclusively established. Therefore, we conducted a meta‐analysis to evaluate the …

GLP-1 receptor agonists in diabetes for stroke prevention: a systematic review and meta-analysis

K Malhotra, AH Katsanos, V Lambadiari, N Goyal… - Journal of …, 2020 - Springer
Background Randomized controlled clinical trials (RCT) have demonstrated varied efficacy
of glucagon-like peptide-1 receptor (GLP-1R) agonists for cardiovascular outcomes. We …

Stroke prevention and treatment in people with type 2 diabetes: is there a role for GLP-1 (Glucagon-Like Peptide-1) Analogues?

DM Williams, M Atkinson, M Evans - Stroke, 2023 - Am Heart Assoc
Stroke is a leading cause of disability and death, and people with type 2 diabetes (T2D)
have a greater risk of stroke and death or disability from stroke. The underlying …

[HTML][HTML] SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort …

A Mascolo, C Scavone, L Scisciola, P Chiodini… - Pharmacological …, 2021 - Elsevier
Despite Sodium-glucose co-transporter-2 (SGLT2) inhibitors have been associated with a
reduced risk of heart failure in patients with type 2 diabetes mellitus (T2DM), the effect …

Impact of glucose-lowering therapies on risk of stroke in type 2 diabetes

F Bonnet, AJ Scheen - Diabetes & metabolism, 2017 - Elsevier
Patients with type 2 diabetes (T2D) have an increased risk of stroke compared with people
without diabetes. However, the effects of glucose-lowering drugs on risk of ischaemic stroke …