A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …

Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …

Background Obesity is a particularly complex disease that at least partially involves genetic
and environmental perturbations to gene-networks connecting the hypothalamus and …

Complex biological systems are best modeled as highly modular, fluid systems exhibiting a
plasticity that allows them to adapt to a vast array of changing conditions. Here we highlight …

Elevated body mass index (BMI) is heritable and associated with many health conditions
that impact morbidity and mortality. The study of the genetic association of BMI across a …

Genome-wide association studies (GWAS) have identified many disease-associated
variants, yet mechanisms underlying these associations remain unclear. To understand …

Obesity is a global epidemic that is causally associated with a range of diseases, including
type 2 diabetes and cardiovascular disease, at the population-level. However, there is …

Background Genome-wide association studies have identified hundreds of loci that
influence a wide variety of complex human traits; however, little is known regarding the …

Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …