Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

The importance of endothelial cell (EC) metabolism and its regulatory role in the angiogenic
behavior of ECs during vessel formation and in the function of different EC subtypes …

Atherosclerosis is a leading cause of morbidity and mortality in Western society. Despite
improved insight into disease pathogenesis and therapeutic options, additional treatment …

Higher organisms rely on a closed cardiovascular circulatory system with blood vessels
supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies …

The endothelium is the orchestral conductor of blood vessel function. Pathological blood
vessel formation (a process termed pathological angiogenesis) or the inability of endothelial …

Angiogenesis has traditionally been viewed from the perspective of how endothelial cells
(ECs) coordinate migration and proliferation in response to growth factor activation to form …

Endothelial cell (EC) metabolism is important for health and disease. Metabolic pathways,
such as glycolysis, fatty acid oxidation, and amino acid metabolism, determine vasculature …

In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …

During vessel sprouting, endothelial “tip” cells migrate at the forefront, while the endothelial
“stalk” cells elongate the sprout; endothelial “phalanx” cells line quiescent vessels. Tip and …

Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …