Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. The brain is one of the organs involved in sepsis, and sepsis-induced …

Brain dysfunction is a common complication after sepsis and is an independent risk factor for
a poor prognosis, which is partly attributed to the dysregulated inflammatory response and …

Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

Sepsis is a massive inflammatory response mediated by infection, characterized by
oxidative stress, release of cytokines, and mitochondrial dysfunction. Melatonin accumulates …

Sepsis is an uncontrolled host response to infection. In some cases, it progresses to multi-
organ insufficiency, leading to septic shock and increased risk of mortality. Various organ …

Septic shock, the most severe problem of sepsis, is a lethal condition caused by the
interaction of a pathogen‐induced long chain of sequential intracellular events in immune …

Sepsis is a systemic inflammatory response to infection that causes severe neurological
complications. Previous studies have suggested that melatonin is protective during sepsis …

Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many
other organs. Melatonin plays an important physiologic role in sleep and circadian rhythm …

Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease with high mortality
and disability rates. Despite progressive advances in drugs and surgical techniques …

Sepsis is a major cause of mortality in critically ill patients and develops as a result of the
host response to infection. In recent years, important advances have been made in …