Previously, we found that the University of North Carolina cystic fibrosis (UNC-CF) mouse
had more severe experimental acute pancreatitis (AP) than wild-type (WT) mice …

Background & Aims: Cystic fibrosis transmembrane regulator (CFTR) gene mutations are
associated with pancreatic insufficiency and pancreatitis. Chronic pancreatitis, including …

The pathophysiologic mechanisms causing inflammation in cystic fibrosis (CF) remain
obscure. The effects of proapoptotic agents on pancreatic and tracheal cell lines expressing …

Mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) are an
established risk factor for cystic fibrosis (CF) and chronic pancreatitis. Whereas patients with …

The recent observation that the severity of pancreatitis is inversely related to the extent of
apoptosis in five experimental models of the disease has suggested the possibility that …

Acute pancreatitis is a disease of variable severity in which some patients experience mild,
self-limited attacks, whereas others manifest a severe, highly morbid, and frequently lethal …

Acute pancreatitis is an inflammatory disorder of exocrine pancreas, which carries
considerable morbidity and mortality; its pathophysiology remains elusive. 1 During the past …

In experimental models of acute pancreatitis (AP), acinar cell death occurs by both necrosis
and programmed cell death or apoptosis. Apoptosis is an active form of cell death …

Acute pancreatitis is an unpredictable disease. Most patients develop edema of the
pancreas and quickly recover whatever the therapy (or lack thereof), but a minority develop …

The factors that determine the severity of acute pancreatitis are unknown, but a close inverse
correlation between that severity and the extent of acinar cell apoptosis that follows the …