H Wu, D Huang, H Zhou, X Sima, Z Wu… - Oncology …, 2022 - spandidos-publications.com
Small‑molecule chemical drugs are of great significance for tumor‑targeted and individualized therapies. However, the development of new small‑molecule drugs, from …
M Kheirandish, H Mahboobi… - Current Drug …, 2018 - ingentaconnect.com
Background: Metformin is widely used for management of Type 2 Diabetes Mellitus (T2DM). Recently growing evidences have shown its anti-cancer effects. The results are mainly from …
Laboratory research and pharmacoepidemiology are providing converging evidence that the widely used antidiabetic drug metformin has antineoplastic activity, but there are …
DR Morales, AD Morris - Annual review of medicine, 2015 - annualreviews.org
Patients with diabetes mellitus are at increased risk of cancer development. Metformin is a well-established, effective agent for the management of type 2 diabetes mellitus …
X Sui, Y Xu, X Wang, W Han, H Pan… - Molecular …, 2015 - ACS Publications
Metformin, a biguanide derivative that is widely used for treating type 2 diabetes mellitus, has recently been shown to exert potential anticancer effects. Many retrospective data and …
F Zi, H Zi, Y Li, J He, Q Shi, Z Cai - Oncology letters, 2018 - spandidos-publications.com
Metformin is a standard clinical drug used to treat type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome. Recently, epidemiological studies and meta‑analyses have …
Background: The anticancer activity of metformin has been confirmed against several cancer types in vitro and in vivo. However, the underlying mechanisms of metformin in the treatment …
A Buczyńska, I Sidorkiewicz, AJ Krętowski… - Cancers, 2022 - mdpi.com
Simple Summary This literature analysis is focused on the pleiotropic action associated with metformin treatment. Precisely, metformin treatment exerts many health effects, mainly by …
J Kasznicki, A Sliwinska, J Drzewoski - Annals of translational …, 2014 - ncbi.nlm.nih.gov
The prevalence of diabetes is dramatically increasing worldwide. The results of numerous epidemiological studies indicate that diabetic population is not only at increased risk of …