[HTML][HTML] Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - Nature …, 2023 - nature.com
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

[HTML][HTML] Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

J Meinhardt, J Radke, C Dittmayer, J Franz… - Nature …, 2021 - nature.com
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

[HTML][HTML] SARS-CoV-2 receptors and entry genes are expressed in the human olfactory neuroepithelium and brain

L Fodoulian, J Tuberosa, D Rossier, M Boillat, C Kan… - Iscience, 2020 - cell.com
Reports indicate an association between COVID-19 and anosmia, as well as the presence
of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium …

COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

GD De Melo, F Lazarini, S Levallois… - Science translational …, 2021 - science.org
Whereas recent investigations have revealed viral, inflammatory, and vascular factors
involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung …

[HTML][HTML] The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys

L Jiao, Y Yang, W Yu, Y Zhao, H Long, J Gao… - Signal transduction and …, 2021 - nature.com
Neurological manifestations are frequently reported in the COVID-19 patients.
Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the …

[HTML][HTML] Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia

M Zazhytska, A Kodra, DA Hoagland, J Frere… - Cell, 2022 - cell.com
SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe
damage in a variety of organs. Thus, deciphering the non-cell-autonomous effects of SARS …

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

DH Brann, T Tsukahara, C Weinreb, M Lipovsek… - Science …, 2020 - science.org
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …

COVID-19-associated olfactory dysfunction reveals SARS-CoV-2 neuroinvasion and persistence in the olfactory system

GD De Melo, F Lazarini, S Levallois, C Hautefort… - BioRxiv, 2020 - biorxiv.org
While recent investigations have revealed viral, inflammatory and vascular factors involved
in SARS-CoV-2 lung pathogenesis, the pathophysiology of neurological disorders in COVID …

[HTML][HTML] Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

M Khan, M Clijsters, S Choi, W Backaert, M Claerhout… - Neuron, 2022 - cell.com
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct and short route from
the nose into the brain? We reasoned that the neurotropic or neuroinvasive capacity of the …