Objective To investigate whether mild motor signs (MMS) in old age correlate with synaptic
density in the brain. Background Normal aging is associated with a decline in movement …

ABSTRACT Background Patients with Parkinson's disease (PD) often develop dementia, but
the underlying substrate is incompletely understood. Generalized synaptic degeneration …

There is some evidence that mild parkinsonian signs (MPSs) are associated with increased
risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims …

Objective Brain iron accumulation has been proposed as one of the pathomechanisms in
Parkinson's disease (PD). This study aimed to examine the whole‐brain pattern of iron …

Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's
disease. Around 30% of patients with Parkinson's disease experience mild cognitive …

Background Cognitive deficits considerably contribute to the patient's burden in Parkinson's
disease (PD). While cognitive decline is linked to neuronal dysfunction, the additional role of …

Background Synaptic dysfunction and degeneration are central contributors to the
pathogenesis and progression of parkinsonian disorders. Therefore, identification and …

Background The objectives of this study were to investigate progressive cortical thinning and
volume loss in Parkinson's disease (PD) patients with different longitudinal patterns of …

Cognitive decline is common in Parkinson's disease (PD), even in the early motor stage, and
this non‐motor feature impacts quality of life and prognosis tremendously. In this article, we …

Objective Greater educational attainment is a protective factor for neurodegenerative
dementias. If education earlier in life leads to greater cerebral reserve, it may play a similar …