Sodium-glucose co-transporter 2 inhibitors and Sarcopenia: a controversy that must be solved

B Afsar, RE Afsar - Clinical Nutrition, 2023 - Elsevier
Diabetes mellitus is a risk factor for muscle loss and sarcopenia. Sodium-glucose co-
transporter 2 inhibitors (SGLT2i) or “gliflozins” are one of the newest anti-hyperglycemic …

Effect of sodium-glucose transporter 2 inhibitors on sarcopenia in patients with type 2 diabetes mellitus: A systematic review and meta-analysis

S Zhang, Z Qi, Y Wang, D Song, D Zhu - Frontiers in Endocrinology, 2023 - frontiersin.org
Objective Sarcopenia has been recognized as the third category of disabling complications
in patients with type 2 diabetes mellitus (T2DM), in addition to micro-and macrovascular …

Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials

R Pan, Y Zhang, R Wang, Y Xu, H Ji, Y Zhao - PLoS One, 2022 - journals.plos.org
Objective Type 2 diabetes mellitus (T2DM) is closely related to sarcopenic obesity (SO).
Body composition measurement including body weight, body mass index, waist …

Relationship between sodium–glucose cotransporter-2 inhibitors and muscle atrophy in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

C Xia, Y Han, C Yin, R Geng, Z Liu, Y Du… - Frontiers in …, 2023 - frontiersin.org
Aim This study aims to assess the association between sodium–glucose cotransporter type-
2 inhibitor (SGLT-2i) treatment and muscle atrophy in patients with type 2 diabetes mellitus …

The Effects of Sodium–Glucose Cotransporter 2 Inhibitors on Body Composition in Type 2 Diabetes Mellitus: A Narrative Review

S Jahangiri, M Malek, S Kalra, ME Khamseh - Diabetes Therapy, 2023 - Springer
Body composition is related to cardiometabolic disorders and is a major driver of the
growing incidence of type 2 diabetes mellitus (T2DM). Altered fat distribution and decreased …

Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats

X Yang, L Wang, L Zhang, X Zhai, X Sheng… - Diabetology & metabolic …, 2023 - Springer
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are commonly used in the
management of type 2 diabetes mellitus (T2DM) and have been found to worsen the …

Improvement of skeletal muscle insulin sensitivity by 1 week of SGLT2 inhibitor use

Y Goto, Y Otsuka, K Ashida, A Nagayama… - Endocrine …, 2020 - ec.bioscientifica.com
Background and Aims: It is currently unclear whether sodium–glucose co-transporter 2
(SGLT2) inhibitor administration can improve the insulin sensitivity as well as rapidly reduce …

Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice

H Otsuka, H Yokomizo, S Nakamura, Y Izumi… - Biochemical …, 2022 - portlandpress.com
There has been a concern that sodium–glucose cotransporter 2 (SGLT2) inhibitors could
reduce skeletal muscle mass and function. Here, we examine the effect of canagliflozin …

[HTML][HTML] Effects of luseogliflozin treatment on hyperglycemia-induced muscle atrophy in rats

K Xie, K Sugimoto, M Tanaka, H Akasaka… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Diabetes mellitus is recognized as a risk factor for sarcopenia. Luseogliflozin, a selective
sodium-glucose cotransporter 2 (SGLT2) inhibitor, reduces inflammation and oxidative …

Sodium‐glucose co‐transporter 2 inhibitors on weight change and cardiometabolic profiles in individuals with overweight or obesity and without diabetes: A meta …

J Wong, KY Chan, K Lo - Obesity Reviews, 2021 - Wiley Online Library
Several meta‐analyses have been conducted to evaluate the weight loss effect of sodium–
glucose cotransporter 2 (SGLT‐2) inhibitors in patients with type 2 diabetes, whereas pooled …