The 26S proteasome is a multisubunit complex responsible for degradation of ubiquitinated
substrates, which plays a critical role in regulating various biological processes. To fully …

The proteasome, a proteolytic complex present in all eukaryotic cells, is part of the ATP-
dependent ubiquitin/proteasome pathway. It plays a critical role in the regulation of many …

Proteasomes are essential in all eukaryotic cells. However, their function and regulation
remain considerably elusive, particularly those of less abundant variants. We demonstrate …

The 26S proteasome plays an essential role in regulating many cellular processes by the
degradation of proteins targeted for breakdown by ubiquitin conjugation. The 26S complex …

The 26S proteasome plays a fundamental role in eukaryotic homeostasis by undertaking the
highly controlled degradation of a wide range of proteins, including key cellular regulators …

▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …

The heart of the ubiquitin-mediated degradation pathway, the 26S proteasome,
endoproteolytically cleaves most intracellular proteins, thereby maintaining biological …

The 26S proteasome is a large,∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …

Proteasome is a highly organized protease complex comprising a catalytic 20S core particle
(CP) and two 19S regulatory particles (RP), which together form the 26S structure. The 26S …

The 26S proteasome is a 2.5 MDa molecular machine for the degradation of substrates of
the ubiquitin-proteasome pathway with a key role in cellular proteostasis. Until recently, only …