A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients

E Garreta, P Prado, M Stanifer, V Monteil, CH del Pozo… - bioRxiv, 2021 - biorxiv.org
SARS-CoV-2 infections lead to a high risk of hospitalization and mortality in diabetic
patients. Why diabetic individuals are more prone to develop severe COVID-19 remains …

[PDF][PDF] A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

E Garreta, P Prado, ML Stanifer, V Monteil, A Marco… - Cell Metabolism, 2022 - cell.com
It is not well understood why diabetic individuals are more prone to develop severe COVID-
19. To this, we here established a human kidney organoid model promoting early hallmarks …

How does diabetes cause susceptibility to COVID-19 in the kidney: new clues provided by organoids

Y Xia, PT Coates, M Nangaku - Kidney International, 2022 - kidney-international.org
Early in the pandemic, diabetes was recognized as a risk factor for poor prognosis in
patients with coronavirus disease 2019 (COVID-19). Although diabetes does not appear to …

Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infection

JM Vanslambrouck, JA Neil, R Rudraraju… - Journal of …, 2024 - Am Soc Microbiol
With a high incidence of acute kidney injury among hospitalized COVID-19 patients,
considerable attention has been focussed on whether SARS-CoV-2 specifically targets …

[HTML][HTML] SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease

R Menon, EA Otto, R Sealfon, V Nair, AK Wong… - Kidney international, 2020 - Elsevier
COVID-19 morbidity and mortality are increased in patients with diabetes and kidney
disease via unknown mechanisms. SARS-CoV-2 uses angiotensin-converting enzyme 2 …

SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury

R Menon, EA Otto, R Sealfon, V Nair, AK Wong… - 2020 - pesquisa.bvsalud.org
ABSTRACT COVID-19 morbidity and mortality is increased in patients with diabetes and
kidney disease via unknown mechanisms. SARS-CoV-2 uses angiotensin-converting …

[HTML][HTML] Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

L Helms, S Marchiano, IB Stanaway, TY Hsiang… - JCI insight, 2021 - ncbi.nlm.nih.gov
Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection
remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited …

[PDF][PDF] Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids

W Rahmani, H Chung, S Sinha, MP Bui-Marinos… - IScience, 2022 - cell.com
COVID-19-associated acute kidney injury (COVID-AKI) is a common complication of SARS-
CoV-2 infection in hospitalized patients. The susceptibility of human kidneys to direct SARS …

[PDF][PDF] SARS-CoV-2 pirates the kidneys: A scar (y) story

J Reiser, R Spear, S Luo - Cell Metabolism, 2022 - cell.com
SARS-CoV-2 can cause diverse severe and lasting damage to the kidneys. In the latest
issue of Cell Stem Cell, Jansen et al. utilized data gleaned from human kidney autopsies …

Discovering hub genes involved in the pathophysiological impact of COVID-19 on diabetes kidney disease by differential gene expression and interactome analysis

U Osuna-Martínez, K Aviña-Padilla, V Olimón-Andalón… - bioRxiv, 2022 - biorxiv.org
Diabetic kidney disease (DKD) is a frequently chronic kidney pathology derived from
diabetes comorbidity. This condition has irreversible damage, and its risk factor increases …