Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

The term “frailty” is used to describe a subset of older adults who appear weaker and more
vulnerable than their age-matched counterparts, despite having similar comorbidities …

An increase in the number of older people experiencing disability and dependence is a
critical aspect of the demographic change that will emerge within Europe due to the rise in …

Background The relationship between age-related frailty and the underlying processes that
drive changes in health is currently unclear. Considered individually, most blood biomarkers …

In the context of accelerated aging of the population worldwide, frailty has emerged as one
of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome …

Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

Even though they would have great benefit across research and clinical fields, currently
there are no accepted biomarkers of frailty. Cross-sectional studies in humans have …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …

The objectives of this literature review were to (1) synthesize biological processes linked to
frailty and their corresponding biomarkers and (2) identify potential associations among …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …