Genetic polymorphisms of IL6 gene–174G> C and–597G> A are associated with the risk of COVID‐19 severity

S Verma, S Verma, FH Khan, Z Siddiqi… - International Journal …, 2023 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19) is pro‐inflammatory disorder characterized
by acute respiratory distress syndrome. Interleukin‐6, a cytokine secreted by macrophages …

Evaluation of the relationship between IL-6 gene single nucleotide polymorphisms and the severity of COVID-19 in an Iranian population

S Falahi, MH Zamanian, P Feizollahi, A Rezaiemanesh… - Cytokine, 2022 - Elsevier
Background Emerged coronavirus disease 2019 (COVID-19) is a pandemic caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Disease severity is …

[PDF][PDF] Polymorphism in promotor region of IL6 gene as a predictor for severity in COVID-19 patients

SA Aladawy, LA Adel, SAA Salam, RH Raafat… - Egypt J Immunol …, 2022 - academia.edu
SARS-CoV-2 is the causative agent of coronavirus disease started in 2019 (COVID-19). IL-6
gene is located on chromosome 7. A considerable number of polymorphisms was identified …

Investigation of the relationship between IL17A, IL17F and ILR1N polymorphisms and COVID‐19 severity: The predictive role of IL17A rs2275913 polymorphism in …

G Cakmak Genc, S Karakas Celik… - International Journal …, 2023 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is an infectious respiratory disease caused
by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Although the mortality …

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

SJA Abbood, E Anvari, A Fateh - Human Genomics, 2023 - Springer
Background Polymorphisms in the interleukin-10 (IL10) gene have been linked to the
severity of the patients infected with the viral infections. This study aimed to assess if the …

Association of polymorphisms of IL-6 pathway genes (IL6, IL6R and IL6ST) with COVID-19 severity in an Amazonian population

FBB Rodrigues, R da Silva, EF Santos, MTFM de Brito… - Viruses, 2023 - mdpi.com
Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an
important regulator of the cytokine storm. Hence, the evaluation of the influence of …

Implication of single nucleotide polymorphisms in Interleukin-10 gene (rs1800896 and rs1800872) with severity of COVID-19

S Rizvi, SMS Rizvi, ST Raza, M Abbas, K Fatima… - Egyptian Journal of …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is an ongoing pandemic which
has emerged as a new challenge for the medical sciences. Severity of COVID-19 is mostly …

[PDF][PDF] Frequency of interleukin-6 rs1800795 (-174G/C) and rs1800797 (-597G/A) polymorphisms in COVID-19 patients in Turkey who develop macrophage activation …

F Kerget, B Kerget - Jpn J Infect Dis, 2021 - niid.go.jp
SUMMARY SARS-CoV-2 (COVID-19) has infected over 100 million people since it
appeared in Wuhan, China just 1 year ago. This study aimed to evaluate the relationship …

Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population

M Rokni, M Sarhadi, M Heidari Nia… - Cell Biology …, 2022 - Wiley Online Library
Cytokines play pivotal functions in coronavirus disease 2019 (COVID‐19) pathogenesis.
However, little is known about the rationale and importance of genetic variations associated …

Impact of IL-6 rs1800795 and IL-17A rs2275913 gene polymorphisms on the COVID-19 prognosis and susceptibility in a sample of Iranian patients

M Khafaei, R Asghari, F Zafari, M Sadeghi - Cytokine, 2024 - Elsevier
Background From asymptomatic to acute and life-threatening pulmonary infection, the
clinical manifestations of COVID-19 are highly variable. Interleukin (IL)-6 and IL-17A are key …