Methylation of cytosine residues in DNA, the best studied epigenetic modification, is
associated with gene transcription and nuclear organization, and ultimately the function of a …

The term 'epigenetics' loosely describes DNA-templated processes leading to heritable
changes in gene activity and expression, which are independent of the underlying DNA …

Rheumatoid arthritis (RA) is a long-term autoimmune disease of unknown etiology that leads
to progressive joint destruction and ultimately to disability. RA affects as much as 1% of the …

The potential roles of epigenetic alterations in the pathogenesis of autoimmune rheumatic
diseases are raising great expectations among clinicians and researchers. Epigenetic …

Aim: A proof-of-concept study to explore whether DNA methylation at first diagnosis is
associated with response to disease-modifying antirheumatic drugs (DMARDs) in patients …

Objective Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly
targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to …

Rheumatoid arthritis (RA) is a complex disease affecting approximately 0.5–1% of the
population. While there are effective biologic therapies, in up to 40% of patients, disease …

Rheumatoid arthritis (RA) is a complex condition that displays heterogeneity in disease
severity and response to standard treatments between patients. Failure rates for …

Genomic predisposition cannot explain the onset of complex diseases, as well illustrated by
the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms …

Objective Epigenetic modifications are dynamic and influence cellular disease activity. The
aim of this study was to investigate global DNA methylation in peripheral blood mononuclear …