During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for
infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than …

BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-
prone, especially with ageing. Such errors markedly reduce the reproductive chances of …

Aneuploidy in human eggs increases with maternal age and can result in infertility,
miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however …

Trisomic and monosomic (aneuploid) embryos account for at least 10% of human
pregnancies and, for women nearing the end of their reproductive lifespan, the incidence …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Chromosome segregation errors in human oocytes lead to aneuploid embryos that cause
infertility and birth defects. Here we provide an overview of the chromosome-segregation …

Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

An increase in the incidence of aneuploidy is well documented with increasing maternal
age, in particular in human females. Remarkably, little is known regarding the underlying …

The cytogenetic investigation of human oocytes was initiated in the Sixties, and for the last
four decades, this field of research has never stopped progressing as new technologies …