Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …

The circadian system orchestrates internal physiology on a daily schedule to promote
optimal health and maximize disease prevention. Chronic disruptions in circadian function …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

Resetting the circadian clock leads to well being and increased life span, whereas clock
disruption is associated with aging and morbidity. Increased longevity and improved health …

The daily recurrence of activity and rest are so common as to seem trivial. However, they
reflect a ubiquitous temporal programme called the circadian clock. In the absence of either …

The goal of this review article is to summarize our knowledge and understanding of the
overlapping (interdisciplinary) areas of senescence, sleep, and circadian rhythms. Our …

Biological rhythms that oscillate with periods close to 24 h (circadian cycles) are pervasive
features of mammalian physiology, facilitating entrainment to the 24 h cycle generated by …

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

Aging is generally associated with weakening of the circadian system. The circadian
amplitude is reduced and the circadian acrophase becomes more labile, tending to occur …

Daily rhythms in behavior and physiology are programmed by a hierarchical collection of
biological clocks located throughout the brain and body, known as the circadian system …